INVESTIGADORES
ALLEGRI Ricardo F.
artículos
Título:
Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient
Autor/es:
ISAJA, LUCIANA; RODRÍGUEZ-VARELA, MARÍA SOLEDAD; MARAZITA, MARIELA; MUCCI, SOFÍA; ITZCOVICH, TATIANA; CHREM-MÉNDEZ, PATRICIO; NIIKADO, MATÍAS; FERRIOL-LAFFOUILLERE, SOFÍA LUJÁN; ALLEGRI, RICARDO; MARTINETTO, HORACIO; SEVLEVER, GUSTAVO EMILIO; SCASSA, MARÍA ELIDA; SURACE, EZEQUIEL IGNACIO; ROMORINI, LEONARDO
Revista:
STEM CELL RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2021 vol. 53
ISSN:
1873-5061
Resumen:
Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male familial Alzheimer´s disease patient carrying the T119I mutation in the PSEN1 gene. PSEN1 genotype was maintained and stemness and pluripotency confirmed in the FLENIi001-A hiPSC line.
