155) Behavioral modifications induced by Ketamine subanaesthetic doses injected 5 to 30 minutes in the forced swimming test.

GUEVARA MA; MARQUEZ HERRERO, S.; SANCHEZ, F.; LAFUENTE, J.V.;; BAIARDI G.; GARGIULO P.A.

Mendoza

Congreso; XXXVI Reunión Anual de la Sociedad de Biología de Cuyo. Resumen 151. Mendoza.; 2018

Sociedad de Biología de Cuyo.

155) Guevara M, Marquez Herrero S, Sanchez F, Lafuente JV, Baiardi G, Gargiulo PA. Behavioral modifications induced by Ketamine subanaesthetic doses injected 5 to 30 minutes in the forced swimming test. XXXVI Reunión Anual de la Sociedad de Biología de Cuyo. Resumen 151. Mendoza. 6 a 7 de Diciembre de 2018.- https://sbcuyo.org.ar/libro-de-resumenes/BEHAVIORAL MODIFICATIONS INDUCED BY KETAMINE SUBANESTHETIC DOSES INJECTED 5 TO 30 MINUTES IN THE FORCED SWIMMING TEST. Guevara M1, Marquez Herrero S1, Sanchez F1, Lafuente JV2, Baiardi G3, Gargiulo PA1 1. Laboratory of Neurosciences and Experimental Psychology. Area of Pharmacology. Faculty of Medical Sciences. National University of Cuyo. CONICET. Mendoza. Argentina. 2. Laboratory of Clinical and Experimental Neurosciences (LaNCE). Department of Neuroscience. University of the Basque Country. Leioa. Spain. 3. Laboratory of Neuropharmacology, Institute of Biological and Technological Research (IIBYT-CONICET). National University of Córdoba. Faculty of Chemical Sciences. Catholic University of Córdoba. 5017. Córdoba. Argentina. E-mail: vetguevara@hotmail.com Ketamine, by antagonizing the NMDA (N-Methyl-D-Aspartic Acid) receptors of glutamate, produces psychotomimetic effects. In previous studies we have verified the action of antagonists of this type injected intraperitoneally in behavioral tests in rats. In the present work the effect of the administration of ketamine at low doses (2.5, 5 mg/kg and saline ip) is studied in the forced swimming test, at 5 and 30 minutes. Holtzman derived rats weighing 280 to 310 g were used. This test is based on the principle of learned hopelessness, which establishes that every organism that is subjected to a stressful event that it cannot control and from which it cannot escape develops, initially, anxiety and subsequently, if the event remains in time, depression. There was a significant decrease in swimming with the dose of 2.5 mg/kg (p