High frequency of primary mutations associated with antirretroviral drug resistance in reclently diagnosed HIV-infection children in Buenos Aires, Argentina

M VIGNOLES; G BARBONI; MR AGOSTI; M GARCÍA; S GONZÁLEZ-AYALA ; H SALOMÓN

Fort Myers, Florida

Workshop; XVIII International HIV DRUG RESISTANCE WORKSHOP - Basic clinical and principal implications; 2009

VA San Diego Healthcare System and University of California San Diego, USA

The aim of our study was to estimate the prevalence of primary HIV drug resistance in a population of children born to HIV-infected mothers in Buenos Aires, Argentina. Our results showed a high frequency of antiretroviral drug resistance mutations in recently diagnosed infants younger than 5 years of age. Therefore, drug resistance testing before HAART inititation in pediatric populations should be implemented as a standard of care, even in developing countries such as Argentina, for a rational and cost-effective use of drugs.