Effect of excess iodine intake on salivary glands in a swiss albino mice model

ROSS, ROMINA; FABERSANI, EMANUEL; RUSSO, MATÍAS; GÓMEZ, ALBA; JAPAZE, HUGO; GONZALEZ, SILVIA; GAUFFIN CANO, PAOLA

BioMed Research International

Hindawi Limited

Lugar: London; Año: 2017

2314-6133

ENVIADO A PUBLICARThe aim of this study was to evaluate the effect of excess iodine ingestion on salivary glands during mating, gestation, lactation (Phase I) and post-weaning period in mouse (Phase II). Before mating until weaning of offspring (Phase I: 42 days) 20 female Swiss albino mice were randomly allocated into two groups:Control (n=10) and Treatment group (n=10) (received supplemented distilled water with NaI 1mg/mL). After weaning, were separated mouse breeding from mother. Offspring were allocated into two groups: Control (n=18) and Treatment group (n=18) (murine offspring who received supplemented iodine water). Phase II last to 35 days. During assay, animals received water (iodine supplemented or not) and normal diet, ad libitum. At the end of Phase I and during Phase II, were analyzed glandular weight, water intake and salivary glands histology. Animals from Treatment groups showed a slight increase in glandular weight and a significantly (p < 0.05) higher water intake than Control groups. An extent of lymphocyte infiltration in animals that ingested iodine in excess, it was observed, while there was no mononuclear infiltration in glandular sections of Control groups. These results demonstrated that iodine excess induced salivary glands lesions, been salivary glands target organs of compounds containing iodine.