INVESTIGADORES
CALVO Juan Carlos
artículos
Título:
Circulating immunoglobulins that inhibit the binding of follicle stimulating hormone to its receptor. A putative diagnostic role in resistant ovary syndrome?
Autor/es:
VIOLETA A. CHIAUZZI; LEONARDO BUSSMANN; JUAN CARLOS CALVO; VICTORIA SUNDBLAD; EDUARDO H. CHARREAU
Revista:
CLINICAL ENDOCRINOLOGY
Referencias:
Año: 2004 vol. 61 p. 46 - 54
ISSN:
0300-0664
Resumen:
OBJECTIVE
To evaluate the presence of circulating
immunoglobulins that inhibit FSH binding to its receptor
(Ig-FSHR) in patients with premature ovarian failure (POF).
DESIGN
Non-randomized study. Blood sampling for
determination of circulating immunoglobulins.
PATIENTS
Two hundred and forty-seven patients with
POF and 60 normally menstruating women (controls).
MEASUREMENTS
Circulating immunoglobulins that
inhibit FSH binding to its receptor were assessed by
FSH-binding inhibition assay.
RESULTS
Twenty-three out of 247 women with POF
presented circulating immunoglobulins that inhibit
FSH binding to its receptor. These patients had been
previously diagnosed as ROS. Sixty control subjects
proved negative.
CONCLUSION
Determination of the presence of circulating
immunoglobulins that inhibit FSH binding to its
receptor could be instrumental in diagnosing the
gonadotropin resistance ovary syndrome.