IQGAP1: A Microtubule-microfilament scaffolding protein with roles in nerve cell development and synaptic plasticity

JAUSORO, I., MESTRES, I., REMEDI, M., SÁNCHEZ, M., AND CÁCERES, A.,

HISTOLOGY AND HISTOPATHOLOGY

F HERNANDEZ

Lugar: Madrid; Año: 2012

0213-3911

In this article, we review our current understanding of the biology of IQ domaincontaining GTPase-Activating Protein 1, IQGAP1, a scaffolding protein with multiple binding partners, which is widely expressed among different cell types including neurons, and capable of linking Rho-GTPase signaling with cytosleletal elements and environmental cues. Quite interestingly, a series of recent studies suggest that IQGAP family members have an important role in neuronal development, synaptic plasticity and nervous system disorders involving alterations in spine density.