Closed - time distribution of ionic channels

C.A. CONDAT; J. JÄCKLE

BIOPHYSICAL JOURNAL

The Biophysical Society

Año: 1989 vol. 55 p. 915 - 925

0006-3495

A one-dimensional version  of the model recently proposed by Lauger (1988) to explain the closed- time distribution of ionic channels in cell membranes is solved analytically. While the probability density f(t) for closed-time lengths may show a well-defined exponential behavior at short times, a power-law decay is predicted at long times. The influence of an additional random distribution of defects in the current-conducting protein  is investigated and found to be dominating at long times. Explicit expressions that may be used for fitting experimental data are given for the closed-time distribution. Some of the available data are discussed and shown to be in good agreement with the predictions of the model.  one-dimensional version  of the model recently proposed by Lauger (1988) to explain the closed- time distribution of ionic channels in cell membranes is solved analytically. While the probability density f(t) for closed-time lengths may show a well-defined exponential behavior at short times, a power-law decay is predicted at long times. The influence of an additional random distribution of defects in the current-conducting protein  is investigated and found to be dominating at long times. Explicit expressions that may be used for fitting experimental data are given for the closed-time distribution. Some of the available data are discussed and shown to be in good agreement with the predictions of the model.