Effect of transport and competition on ligand binding

C.A. CONDAT; P.P. DELSANTO; E. RUFFINO; G. PEREGO

BIOPHYSICAL CHEMISTRY

Elsevier Science

Año: 1999 vol. 76 p. 185 - 198

0301-4622

We present a model to describe the physics of chemoreception in processes determined by competitive ligand binding. Our model describes the competition between various populations, such as ligands vs. blockers and receptors vs. decoys, in protein activation when diffusion is rate-determining. Full spatio-temporal solutions can be obtained numerically. The model structure is kept simple enough as to permit its easy generalization to describe a large subset of the manifold of possible situations occurring in nature. The power and simplicity of the proposed method are exhibited through the solution of several examples which are discussed in detail.