A Simple Model for the Interaction Between T. cruzi and its Antibodies during Chagas Infection

S. COSSY ISASI; G.J. SIBONA; C.A. CONDAT

JOURNAL OF THEORETICAL BIOLOGY

Elsevier

Año: 2001 vol. 208 p. 1 - 13

0022-5193

The evolution of the acute phase of the Chagas infection is analysed from the viewpoint of the dynamic competition between parasite and antibody populations. A simple model for the growth and annihilation of these populations is shown to provide a suitable description of the experimental data. We also "nd that it is possible to classify antibody response to"nd that it is possible to classify antibody response to ¹rypanosoma cruzi, into three main cases, de"ned by antibody e$ciency, initial number and creation rate. The model clearly indicates the most relevant parameters determining the evolution of the Chagas infection, yielding a simple asymptotic criterion for the host survival.rypanosoma cruzi, into three main cases, de"ned by antibody e$ciency, initial number and creation rate. The model clearly indicates the most relevant parameters determining the evolution of the Chagas infection, yielding a simple asymptotic criterion for the host survival.