Meet Our Editorial Board Member:

BAUTISTA RODRIGUEZ, JUAN

MINI-REVIEWS IN MEDICINAL CHEMISTRY

BENTHAM SCIENCE PUBL LTD

Año: 2015 vol. 16 p. 2 - 2

1389-5575

Juan Bautista Rodriguez was born in Buenos Aires. He received his B.Sc. at Universidad de Buenos Aires (1982), his Ph.D. at Universidad de Buenos Aires (1990) in synthetic organic chemistry under Prof. Eduardo G. Gros. Then, he was a Postdoctoral Fellow at the National Institutes of Health, National Institute of Mental Health under Sanford P. Markey (1992), and at the National CancerInstitute under Victor E. Marquez (1993). He was appointed Assistant Professor, and then Professor both at Universidad de Buenos Aires where he set up a medicinal chemistry research group focused on parasitic and viral diseases. His active areas of research include molecular recognition, medicinal chemistry, organophosphorus chemistry and synthetic organic chemistry. He has made relevant contributions in these fields.For example, the development of WC-9, a potent growth inhibitor of the responsible agent of Chagas disease, Trypanosoma cruzi, targeting squalene synthase is noteworthy. The design of linear bisphosphonates as effective and selective inhibitors of T. cruzi and Toxoplasma gondii proliferation whose primary target is farnesyl pyrophosphate synthase. The development ofphosphinopeptides against T. cruzi, which is designed as inhibitors of simple structures that acted as mimics of the transition state of trypanothione synthase. In addition, Dr. Rodriguez was involved in the design and synthesis of conformationally locked carbocyclic nucleosides, taken the naturally occurring neplanocin C, a representative member of the neplanocin family of antibiotics, as a reference structure. The synthesis of metabolically stable analogues of this compound led to the development of N-methane-carba-thymidine, an extremely potent anti herpetic agent. In this context, he was able to synthesizeenantioselectively many members of this family of compounds comprising the first enantioselective synthesis of neplanocin C, their 2? desoxyanalogues, (+)-neplanocin F, and others. Besides of being member of the Editorial Advisory Board of Mini Reviews in Medicinal Chemistry, he is currently member of the Editorial Advisory Board of Journal of Medicinal Chemistry (American Chemical Society), OA Drug Design & Delivery (OA Publishing London), Recent Patent Reviews on Anti -Infective Drug Discovery (Bentham Science Publishers), Journal of Biochemistry and Molecular Biology Research, International Journal of Drug Design and Discovery (Pharma Book Syndicate).He was Executive Guest Editor of Current Pharmaceutical Design for a hot topic issue devoted to tropical diseases, which was published in 2001. He was also member of the EAB of Medicinal Chemistry Reviews ? on Line (Bentham Science Publishers, 2004-2005).He was recognized as an Outstanding Reviewer of Journal of Medicinal Chemistry, American Chemical Society in 2012.He also received the ?Dr. L. Guglialmelli? Prize from the Argentinean Chemical Association, AQA (1990-1991). He is a current member (Principal Investigator) of the National Research Council of Argentine (CONICET).