INVESTIGADORES
RODRIGUEZ Juan Bautista
artículos
Título:
Design, Synthesis and anti-Trypanosoma cruzi Evaluation of a New Class of Cell Growth Inhibitors Structurally Related to Fenoxycarb
Autor/es:
SCHVARTZAPEL, ANDREA JUDITH; FICHERA, LAURA; ESTEVA, MÓNICA; RODRIGUEZ, JUAN BAUTISTA; GROS, EDUARDO GERVASIO
Revista:
HELVETICA CHIMICA ACTA
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Año: 1995 vol. 78 p. 1207 - 1214
ISSN:
0018-019X
Resumen:
Several compounds, structurally related to the insect-growth regulator Fenvxycarb (l), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanmvma cruzi cells (epimastigotes). Compounds 6,16, 18, and 22 were very active against 7. cruzi making them promising good candidates either for blood-bank sterilization or Chugas-disease surveillance, while compounds 11, 12,13, and 19 showed a moderate degree of activity.Fenvxycarb (l), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanmvma cruzi cells (epimastigotes). Compounds 6,16, 18, and 22 were very active against 7. cruzi making them promising good candidates either for blood-bank sterilization or Chugas-disease surveillance, while compounds 11, 12,13, and 19 showed a moderate degree of activity.
