Preparation of 2(R) and 2(S) Methyl-2-Methylglycerates

RODRIGUEZ, JUAN BAUTISTA; MARKEY, SANFORD P.; ZIFFER, HERMAN

TETRAHEDRON-ASYMMETRY

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1993 vol. 4 p. 101 - 108

0957-4166

Optically pure samples of both enantiomerosf methyl 2,3-dihydroxy-2-methyl- propanoate were prepared by a chromatographic separation of their (-)-menthyl esters followed by hydrolysis and methylation. Their absolute stereochemistries were established by conversion into their 3-O-acetyl derivatives, compounds of established confignralion. NMR and CG-MS methods of determining the optical purities of the diols are described.