Design, Synthesis and Biological Evaluation of New Growth Inhibitors of Trypanosoma cruzi (Epimastigotes)

SCHVARTZAPEL, ANDREA JUDITH; ZHONG, LI; DOCAMPO, ROBERTO; RODRIGUEZ, JUAN BAUTISTA; GROS, EDUARDO GERVASIO

JOURNAL OF MEDICINAL CHEMISTRY

AMER CHEMICAL SOC

Lugar: Columbus; Año: 1997 vol. 40 p. 2314 - 2322

0022-2623

As a continuation of our project aimed at the search for new chemotherapeutic agents against Chagas’ disease, several drugs structurally related to the insect growth regulator Fenoxycarb and the naturally occurring juvenile hormone of insects were designed, synthesized, and evaluated as antiproliferative agents against the parasite responsible of this disease. Isoprenoid derivatives (compounds 33, 34, 36, and 37) were potent growth inhibitors of Trypanosoma cruzi epimastigotes. In addition, taking into account the high activity observed for compound cruzi epimastigotes. In addition, taking into account the high activity observed for compound 33, 34, 36, and 37) were potent growth inhibitors of Trypanosoma cruzi epimastigotes. In addition, taking into account the high activity observed for compoundepimastigotes. In addition, taking into account the high activity observed for compound 30 and the inhibitory action of related compounds, the allyl ether moiety bonded at the polar extreme of these inhibitors proved to be a promising group for the design of new drugs. extreme of these inhibitors proved to be a promising group for the design of new drugs. and the inhibitory action of related compounds, the allyl ether moiety bonded at the polar extreme of these inhibitors proved to be a promising group for the design of new drugs.