Bisphosphonates Derived from Fatty Acids are Potent Growth Inhibitors of Trypanosoma cruzi

SZAJNMAN, SERGIO HERNÁN; BAILEY, BRIAN N.; DOCAMPO, ROBERTO; RODRIGUEZ, JUAN BAUTISTA

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2001 vol. 11 p. 789 - 792

0960-894X

We have investigated the effect of a series of bisphosphonates derived from fatty acids against Trypanosoma cruzi proliferation in in vitro assays. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption, their potential innocuousness makes them good candidates to control tropical diseases.