Does the brain have memory for eating behaviour? Effects of neonatal overfeeding on male rats exposed to a cafeteria diet in adulthood.

FERNANDEZ PR; CANESINI G; SCHUMACHER R; GAYDOU L; ROSSETTI MF; GARCÍA, ANA PAULA; RAMOS JG; STOKER C

Congreso; CONGRESO IBRO 2023; 2023

INTERNATIONAL BRAIN RESAEARCH ORGANIZATION

Our objective was to study the impact of neonatal overfeeding on the orexigenic response to acafeteria diet (CAF) in adulthood. Male Wistar rats were raised in small litters (4 pups/dam, SL)or normal litters (10 pups/dam, NL). From weaning they were fed with standard chow, control diet(CON) until postnatal day 90 (PND90). From PND90 and for 11 weeks the animals received CON(3 kcal/g) or palatable occidental-style cafeteria diet (CAF) (4,85 kcal/g), (NL-CON, NL-CAF, SLCON, SL-CAF; 10-14 rats/group). Body weight and food intake were recorded weekly. ElevatedPlus Maze (EPM) and Specific Sensory Satiety test (SSS) were performed at the end ofexperience separated by 15 days. Blood and fat pads were obtained at sacrifice. CAFconsumption significantly increased body weight (p