INVESTIGADORES
MATA Ernesto Gabino
artículos
Título:
In vitro anticancer activity and SAR studies of triazolyl aminoacyl(peptidyl) penicillins
Autor/es:
CORNIER, PATRICIA G.; DELPICCOLO, CARINA M.L.; MASCALI, FLORENCIA; BOGGIAN, DORA; MATA, ERNESTO G; CÁRDENAS, MARIANO G.; BLANCK, VIVIANA; ROGUIN, LEONOR P.
Revista:
Medicinal Chemistry Communication
Editorial:
Royal Society of Chemistry
Referencias:
Lugar: Londres; Año: 2014 vol. 5 p. 214 - 218
ISSN:
2040-2503
Resumen:
A library of triazolyl aminoacyl(peptidyl) penicillins was designed, synthesized, and evaluated for their antiproliferative activity against HeLa and B16-F0 cell lines. Structure?activity relationship studies were carried out, and minimal structural requirements were determined. Among the tested compounds, derivatives 7f, 7p and 7m demonstrated the highest anticancer activity and a promising selectivity profile against these two cell lines
