Permethylated b-cyclodextrin in liquid poly(oxyethylene) as stationary phase for capillary gas chromatography

OSORIO GRISALES, J.; LEBED, P. J.; KEUNCHKARIAN, S.; GONZÁLEZ, F. R.; CASTELLS, C. B.

JOURNAL OF CHROMATOGRAPHY - A

Elsevier

Lugar: Amsterdam; Año: 2009 vol. 1216 p. 6844 - 6855

0021-9673

This paper reports the study of poly(oxyethylene) as a solvent for heptakis(2,3,6-tri-O-methyl)-b-cyclodextrin (PM-b-CD) and the potential of these mixtures for constructing enantioselective gaschromatography columns. Enantioseparations of volatile racemic mixtures using capillaries coatedwith 10–50% PM-b-CD diluted in Carbowax 20M were evaluated. The influence of the polymertype on retention, separation and reproducibility over a period of time is critically discussed. Thepoly(oxyethylene)-based columns were also compared to columns prepared by dilution of PM-b-CDin two polysiloxanes, SE-30 and SE-54, at several temperatures. Finally, we evaluated a new stationary phase prepared by crosslinking the chiral selector to the poly(oxyethylene) matrix.