INVESTIGADORES
CARANDO Daniel German
congresos y reuniones científicas
Título:
Detailed Dosimetry and Clinical Outcome Analysis for the Argentine BNCT Trials of Cutaneous Nodular Melanomas
Autor/es:
GONZÁLEZ SARA; CASAL, MARIANA; SANTA CRUZ, GUSTAVO; BONOMI, MARCELO; JIMÉNEZ REBAGLIATI, RAÚL; CARANDO, DANIEL; ET AL
Lugar:
Takamatsu, Kagawa, Japón
Reunión:
Congreso; the Twelfth International Congress on Neutron Capture Therapy; 2006
Resumen:
Three
female patients with biopsy-proven nodular melanoma were treated to six
separate sites as part of the Phase I/II BNCT clinical trial conducted at the
Comisión Nacional de Energía Atómica (CNEA) and the Instituto A. Roffo,
Argentina. This work reports on the detailed dosimetry for the clinical trials,
and presents a preliminary analysis to investigate the possible influence of
tumor size and total equivalent dose on the observed local tumor response.
Also, the appropriateness of applying a 3.5 tumor-to-blood 10B
concentration ratio for the BPA compound in nodular melanoma cases is
discussed. The statistical analysis showed that tumor response depends not only
on the dose but also, and highly, on the tumor size. For these three patients,
there was no significant difference between minimum and mean equivalent doses
as explicative for tumor response. The collection of sixteen experimental-based
tumor-to-blood ratios determined by CNEA in nodular melanoma patients derived
an average value and standard deviation of 2.5 ± 0.6. This result suggests that
a lower ratio could be more suitable for estimating the clinical dosimetry. It
is also consistent with the worse tumor control rate in nodular melanomas
observed by other researchers.