CORNEAL ANTI OXIDATIVE MECHANISMS MALFUNCTION ARE INVOLVED IN THE GENESIS OF CLIMATIC DROPLET KERATOPATHY

M FERNANDA SUAREZ; HORACIO M. SERRA

Top 10 Contributions on Ophthalmology

Avidscience

Año: 2019; p. 1 - 31

disease of unknown etiology. We described CDK for the first timein Latin America in the Argentinean Patagonia (El Cuy). A deeperknowledge of CDK pathogenic mechanisms will provide new therapeuticstrategies. For that reason we investigated the prevalence ofCDK in El Cuy and its existence in other 3 provinces with similar climate.Patients eye were exanimate, inquired about habits throughoutlives and serum ascorbate (sAA) determined. All individuals workoutdoors for most of the day. All regions had normal O3 levels. Individualsfrom regions 1, 2, and 3 had very low consumption of vegetables/fruits and low sAA levels. Conversely, region 4 individuals hadbalanced diet and higher sAA concentrations. CDK was only foundin region 3 where individuals had partial deficiency of sAA and didnot use eye protection.No CDK was found in regions 1 and 2 where individuals hadsimilar work activities and dietary habits to those in region 3 but weareye protection. No disease was found in region 4 where individualswork outdoor, have balanced diet and use eye protection. To summarize,the CDK existence was not only related to climate but also to thedietary habits and lack of protection to sunlight.