IBR 13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Bacterial sensing of and resistance to gold salts
Autor/es:
SUSANA K. CHECA; MARTÍN ESPARIZ; MARÍA E. PÉREZ AUDERO; PABLO E. BOTTA; SILVANA V. SPINELLI; FERNANDO C. SONCINI
Revista:
MOLECULAR MICROBIOLOGY
Editorial:
Blackwell Publishing Ltd
Referencias:
Año: 2006 vol. 63 p. 1307 - 1318
ISSN:
0950-382X
Resumen:
Aceptado 21/12/2006.Publicado en 2007.-The MerR family is a group of bacterial transcriptionalregulators that respond to different environmentalstimuli, such as heavy metals, oxidative stress orantibiotics. Here we characterize a new member ofthis family that is highly selective for Au ions. Weshow that this Salmonella regulator, named GolS,directly controls the expression of at least twotranscriptional units specifically required for Auresistance. By chromosomal mutagenesis, we demonstratedthat Au-selectivity is accomplished by ametal-binding motif in GolS. Among the monovalentmetal-ion sensing MerR regulators GolS clustersin a branch distant from enterobacterial CueRorthologues. We propose that GolS and its homologuesevolved to cope with toxic concentration of Auion, allowing microorganisms to withstand contaminatedenvironments.
