IDIM 12530
INSTITUTO DE INVESTIGACIONES MEDICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Leptin-Thyroliberin Pathway in Left Ventricle Hypertrophy
Autor/es:
PERES DIAZ, LUDMILA S.; LANDA, MARÍA SILVINA; AISICOVICH, MAIA; TOBLLI, JORGE EDUARDO; SCHUMAN, MARIANO LUIS; GARCÍA, SILVIA INÉS
Lugar:
New Orleans
Reunión:
Congreso; Council on hypertension; 2019
Institución organizadora:
American Heart Association
Resumen:
Cardiac TRH (cTRH) induces LVH and fibrosis. The adiponectin Leptin induces TRH in CNS. We hypothesized that in obesity, the increase of cTRH induced by hyperleptinemia is responsible for the LVH, mostly attributed to pressure load. We studied obese hyperleptinemic with mild hypertension Agouti mice, and found LVH with higher (p
