IDIM 12530
INSTITUTO DE INVESTIGACIONES MEDICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
CARDIAC LEPTIN-TRH INTERACTION IN THE LEFT VENTRICULAR HYPERTROPHY OF THE OBESE MOUSE.
Autor/es:
MARIANO L. SCHUMAN; SILVIA I GARCÍA; PERES DIAZ LUDMILA; MARÍA S. LANDA; MAIA AISICOVICH; JORGE E TOBLLI
Lugar:
Mar del Plata
Reunión:
Congreso; XXVI Congreso Argentino de Hipertension Arterial; 2019
Institución organizadora:
International Society of Hypertension y Sociedad Argentina de Hipertensión
Resumen:
Cardiac TRH induces left ventricular hypertrophy (LVH)and fibrosis, its inhibition prevents hypertrophy. The adiponectin leptininduces TRH in CNS. We hypothesized that in obesity, the increase of TRHinduced by hyperleptinemia is responsible for the LVH, until now mostlyattributed to pressure load. We studied obese Agouti mice sufferinghypertension with hyperleptinemia and found LVH with increased TRH gene expression.Consequently we found higher (p
