A NEW DEPRESIÓN ANIMAL MODEL: NEONATAL TREATMENT WITH CLOMIPRAMINE FACILITATES THE RECUPERATION ON FRUSTRATION.

RUETTI, E. M.; JUSTEL, N. R.; MUSTACA, A. E.

Buenos Aires

Congreso; 14th Biennial Meeting International Society for Comparative Psychology Argentinean Scientific Society Av.; 2008

The neonatal administration of clomipramine produces fisiological, neuroendocrinal and behavioural anormalities when the rats become adults, they are similar to the ones observed in human depression. It was found that the administration of antidepressants normalizes these alterations. The experimental animals recibe a subcutaneous administration of clomipramine (15 mg/kg), twice a day, since the 8 to 21 posnatal day. The goal of the present report is to study if the neonatal treatment with clomipramine changes the anxiety responses when the animals are adults. The animals are exposed to a forced swim test, to check that they present depressive behaviour. The clomipramine treated animals present more immobility than the control group. In experiment 1, used a procedure Contrast Sucesive Negative consummatory (CSNc). The newborn animals treated with clomipramine showed a faster recovery of frustration, compared with controls animal. In experiment 2, a Contrast Anticipatory (CA) was realized, to control potential cognitive effects involved in the previous experiment. All animals presented an anticipatory response, but there were no significant differences among animals who received treatment with neonatal clomipramine and controls. The animals treated with neonatal clomipramine show a faster recovery of frustration, but do not have a cognitive impairment to the presentation of different rewards.