Glucagon Like peptide 1 (GLP1) and central control of body weight

BURGUEÑO AL; GONZALES MANSILLA NL; FERNANDEZ GIANOTTI T; SOOKOIAN S; PIROLA CJ

San Pablo

Congreso; 6th Congress of the International Society of Nutrigenetics/Nutrigenomics; 2012

International Society of Nutrigenetics and Nutrigenomics

Background: Glucagon Like Peptide 1 (GLP1) is a small intestine-derived hormone secreted from gut L-cells in response to food intake. Circulating GLP1 has a half life of 1-2 minutes owing to the dipeptidyl peptidase 4 (DPP4)-mediated-degradation. Besides its well-known anti-hyperglycaemic effects, GLP1 has also been involved in the regulation of food intake, body weight and cardiovascular function. Objectives : our aim was to study whether GLP1 and leptin shared common energy balance regulation pathways. Methods: We used 32 male 20 weeks-old Wistar rats, 8 rats were feed ad-libitum group (controls) and 24 rats were fasted for 72 hs. During fasting, 8 rats/group, received leptin (10ug/rat), exenatide (5ug/rat) or vehicle (phosphate buffered saline with 0.1% bovine serum albumin) every 12hs. We recorded daily body weight and arterial blood pressure. At the end of the experiment, animals were kill, diencephalon was dissected, plasma collected and visceral white adipose tissue weighed. Results: Fasting produced notorious decrease in: body weight (p