NIR-Fluorescent sensor for Zn2+ derived from a tricarbocyanine

CECILIA SAMANIEGO LOPEZ; GUILLERMO MENENDEZ; CARLA C. SPAGNUOLO; ELIZABETH JARES-ERIJMAN

Córdoba

Encuentro; XI ELAFOT; 2012

Univ Nac Río Cuarto

Tricarbocyanines are fluorescent molecules with absorption and fluorescence emission in the near infrared región (650-950 nm) with excellent water solubility and outstanding dyes for bioanalytical applications[1]. Especially, chlorotricarbocyanine 1 is versatile precursor due to the simple substitution reaction that undergo with a convenient nucleophile. A variety of residues could be introduced by substituing the chlorine atom, in particular receptor fragments for certain analytes like cations, anions or neutral molecules that serves as ligands for specific labeling of biomolecules or cellular structures in vivo in fluorescence microscopy studies[2]. In this work we present the synthesis and characterization of a sensor 2 for cation Zn2+ derived from tricarbocyanine 1 upon reaction with di(2-picolil)ethylenediamine (DPEN). We discuss the optical properties of the compound and describe the sensing performance and selectivity by means of fluorescence steady-state and time-resolved techniques.