INQUIMAE 12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Study of oxygen binding in Mycobacterium tuberculosis TrHbO when interacting with lipid bilayers
Autor/es:
ESTRIN, DARÍO A.; CAPECE, LUCIANA; BRINGAS, MAURO
Lugar:
San Luis
Reunión:
Congreso; Reunión Anual de la Sociedad Argentina de Biofísica; 2019
Institución organizadora:
Sociedad Argentina de Biofisica
Resumen:
Truncated hemoglobin O (TrHbO) of Mycobacterium tuberculosis (Mt) is a small hemeprotein that is known to be vital in the microorganism?s capacity to resist microaerobic conditions1; GlbO knockout Mt is not able to survive under hypoxic stress. This globin exists mostly as a dimer in solution2, and it is able to perform an autokinase activity under low oxygen concentration conditions. Our aim is to describe both computationally and experimentally the interaction between monomeric TrHbO of Mt and negatively charged membranes
