CONICET | Buscador de Institutos y Recursos Humanos

The signalling agents involved in cellular communication display wide chemical diversity. During the lastdecades, the rise of a new group of transmitters instigated the revision of traditional concepts of intercellular signalling.Gasotransmitters are a family of soluble molecules, either endogenously synthesized or from exogenousorigin, which transmits chemical signals that can induce certain physiological or biochemical changes. Thesesmall reactive (and usually transient) species are constantly being produced, trafficked, consumed or transformedin biological environments. Fluorescent probes based on transition metal complexes offer powerful tools to studychemical reactions in the laboratory, through in vitro experiences, and well as the in vivo biochemistry of gasotransmittersin their native environments, as long as minimal disturbance to living systems is ensured. Fundamentalorganic, organometallic and inorganic reactivity principles, combined with an eye towards biological imagingapplications, have given rise to a variety of new chemical tools for probing the complex roles of small moleculesin physiology and pathology. In this work, we present different compounds and tactics to use such probes for thedetection and quantification of these biologically relevant chemical analytes.