INQUIMAE 12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
artículos
Título:
Photoactivation of anticancer Ru complexes in deep tissue: How deep can we go?
Autor/es:
SUN, WEN; ZENG, XIAOLONG; SLEP, LEONARDO DANIEL; WU, SI; THIRAMANAS, RAWEEWAN; MAILANDER, VOLKER
Revista:
CHEMISTRY-A EUROPEAN JOURNAL
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Año: 2017 vol. 23 p. 10832 - 10837
ISSN:
0947-6539
Resumen:
Activation of anticancer therapeutics such as ruthenium(Ru) complexes is currently a topic of intense investigation. Thesuccess of phototherapy relies on photoactivation of therapeuticsafter the light passes through skin and tissue. In this paper, we studythe photoactivation of anticancer Ru complexes with 671-nm redlight through tissue of different thicknesses. We synthesized fourphotoactivatable Ru complexes with different absorptionwavelengths. Two of them (Ru3 and Ru4) were responsive towavelengths in the ?therapeutic window? (650-900 nm) and could beactivated using 671-nm red light while the other two (Ru1 and Ru2)could not be activated using red light. We demonstrated that 671-nmlight can activate Ru3 and Ru4 after passing through tissue up to 16-mm-thick. Furthermore, after passing through an 8-mm-thick tissue,671-nm light activated Ru4 and caused inhibition of cancer cells.These results suggest that photoactivatable Ru complexes arepromising for applications in deep-tissue phototherapy.
