INQUIMAE 12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
artículos
Título:
The role of protein dynamics and thermal fluctuations in regulating cytochrome c / cytochrome c oxidase electron transfer
Autor/es:
ALVAREZ PAGGI, D.; ZITARE U.; MURGIDA D.H.
Revista:
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2014 vol. 1837 p. 1196 - 1207
ISSN:
0005-2728
Resumen:
In this overview we present recent combined electrochemical, spectroelectrochemical, spectroscopic and computational studies from our group on the electron transfer reactions of cytochrome c and of the primary electron acceptor of cytochrome c oxidase, the CuA site, in biomimetic complexes. Based on these results, we discuss how protein dynamics and thermal fluctuations may impact on protein ET reactions, comment on the possible physiological relevance of these results, and finally propose a regulatory mechanism that may operate in the Cyt/CcO electron transfer reaction in vivo.
