IIBBA 05544
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BUENOS AIRES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Plasma membrane calcium ATPase downregulation in dopaminergic neurons in Drosophila melanogaster reflects features of Parkinson?s disease
Autor/es:
MARÍA SILVINA MARCORA; RODOLFO TARELLI; DIEGO HERNÁN BODIN; ANA LAURA DE LELLA EZCURRA; MARÍA ISABEL FARÍAS; LÍA FRENKEL; BERENICE ANABEL SILVA; CHRISTIAN HÖCHT; CARINA CINTIA FERRARI; MARÍA CELESTE LEAL; ARIEL CHERNOMORETZ; FERNANDO JUAN PITOSSI; BRENDA ERHARDT; JUAN CRUZ CASABONA; PABLO ALEJANDRO BOCHICCHIO; VERÓNICA LUCÍA CAVALIERE CANDEDO; MIGUEL ÁNGEL ALLO; EDUARDO MIGUEL CASTAÑO
Lugar:
Valparaíso
Reunión:
Simposio; Small brains big ideas; 2019
Institución organizadora:
Universidad de Valparaíso
Resumen:
Parkinson?s disease (PD) is characterized by a progressive death of dopaminergic neurons (DN) within the substantia nigra. The molecular bases of the DN degeneration are unknown. DN show a peculiar pacemaker activity to release dopamine that is dependent on elevating intracellular calcium (Ca) concentrations.It has been proposed that a slow but consistent increment of Ca could be responsible for aged DN death.The aim of this study is Understand why the dopaminergic neurons of the substantia nigra are selectively degenerated in PD, by defining if plasma membrane calciumATPase (PMCA1) contributes to the vulnerability of the DN.
