IIBBA 05544
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BUENOS AIRES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Rock inhibition induces synthetic lethality in BRCA2 deficient cell lines
Autor/es:
PAVIOLO, NATALIA S.*; CARABAJOSA GONZÁLEZ, SOFÍA; VANESA GOTTIFREDI; JULIETA MARTINO*; JOSÉ LUIS BOCCO; MARIA FLORENCIA PANSA; GASTÓN SORIA
Reunión:
Jornada; Jornada de Ciencia en el Leloir; 2018
Institución organizadora:
Fundación Instituto Leloir
Resumen:
Apromising strategy which takes advantage of the frequent impairment of DNArepair pathways in tumor cells is synthetic lethality (SL). Loss of theHomologous Recombination Repair (HRR) capacity is frequent in breast andovarian cancer. In those patients, normal cells are HRR proficient andtherefore, the accumulation of HRR substrates should selectively cause celldeath in HRR defective cancer cells but not in normal cells. These hypothesishas been validated using Poly(ADP-ribose) polymerase inhibitors (PARPi); (i.e: Olaparib),therefore prompting the systematic search for better and more specific SL inducers. *Equal Contribution to this work
