A NOVEL LINK BETWEEN CELLULAR STRESS AND NEURODEGENERATION

PÉREZ-PEPE, MARCELO; KATS, MAXIMILIANO; BOCCACCIO, GRACIELA L; LA SPINA, PABLO; WAPPNER, PABLO; LAROTONDA, LETICIA; FERNÁNDEZ ALVAREZ, ANA JULIA

Buenos Aires

Congreso; Reunion Conjunta de Sociedades de Biociencias; 2017

Cellularstress is a common feature in diverse pathologies, including cancer andneurodegeneration. Several stress factors trigger a global translational shutdown, while the translation of protective proteins is facilitated. The mRNAsthat aren?t translated form large cytoplasmic aggregates termed Stress Granules(SGs). SG formation is conserved in mammalian, insects, yeasts, trypanosomesand plants. SGs are transient and highly dynamic and their contribution to thestress-induced translational reprogramming or to cell survival remains unknown.SGs contain mRNAs trapped inabortive translation initiation complexes and RNA-binding proteins involved inreprogramming mRNA translation and decay. Anumber of abnormal protein aggregates present in neurodegenerative conditions(TDP43, SMN, FUS/TLS, among others) are related to SGs (Benseñor et al., 2011).