IIBBA 05544
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BUENOS AIRES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Modulation of activity by running speed in the circuits of the rat entorhinal cortex
Autor/es:
EMILIO KROPFF
Reunión:
Conferencia; Reunion Anual de la Sociedad Argentina de Neurociencias 2013; 2013
Resumen:
Al ser un evento sin publicacion, adjunto su programa.
Abstract:
The Entorhinal Cortex of
the rodent brain contains neurons - grid cells - whose activity correlates
outstandingly with the position of the animal in space, disregarding all other
behavioral variables. It has been proposed that they form a Cartesian-like
frame of reference that serves as the main source of spatial input to the
Hippocampus, though the exact mechanism that allows this is not yet clear. Some
of the main current theoretical models that account for grid cell firing state
that these neurons integrate a velocity signal that is coded either in the
population oscillations of the network at the theta frequency band or in the
firing rate of a selected group of Entorhinal cells, suggesting that running
speed is a crucial element of the network dynamics. Following the introduction
of a novel experimental setup that allows us to control the running speed of
rats while we record their neural activity, we will evaluate how well the
current perspectives of circuit oscillation and single cell coding can explain
our results, thus closing the loop between experiments and theory.
