Activity-dependent neuronal maturation in the adult hippocampus

ALVAREZ, DIEGO; M. GEORGINA DAVIES-SALA; DAMIANA GIACOMINI; ALEJANDRO F. SCHINDER

Huerta Grande, Córdoba

Congreso; XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencia; 2012

Sociedad Argentina de Investigación en Neurociencia

The dentate gyrus (DG) of the hippocampus generates neurons throughout life. In previous works of our lab it was shown that the sequence of neuronal maturation in the adult DG resembles the development sequence. In addition, it was demonstrated that a differential maturation rate exists along the longitudinal axis of the hippocampus, and that the maturation rate can be modulated by physiological conditions such as voluntary exercise. Moreover, it was shown that, in sedentary conditions, newborn neurons developing on the septal pole of the hippocampus mature faster than those that develop on the temporal pole. In exercise conditions, newborn neurons developing on the temporal pole increase their maturation rate,equalizing with those of the septal pole, and this effect depends both on local network activity and intrinsic activity of the developing neuron