IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effects of Enalapril on Sexual Hormones and on Nitric Oxide System Activity in the Kidney, Heart and Aorta
Autor/es:
ZILBERMAN JUDITH; VEIRAS LUCIANA; MINOTTI N; BIANCCIOTTI A; VILLAMIL A; COSTA MARIA DE LOS ANGELES; ARRANZ CRISTINA
Lugar:
San Diego, USA.
Reunión:
Congreso; Experimental Biology; 2008
Institución organizadora:
American Physiology Society
Resumen:
Studies in animal models suggest that sexual hormones, oxidative
stress, and impaired nitric oxide (NO) system and renin-angiotesin
system activation play a role in hypertension during menopause.
However, the involved mechanisms are still unknown.
Objective: To evaluate the effects of enalapril, an inhibitor of the
angiotesin-converting enzyme (ACE), on systolic blood pressure
(SBP), sexual hormones and NO syntase (NOS) activity in
normotensive menopausal rats.
Wistar rats were ovariectomized, and ten weeks later were divided
into two groups: Experimental (E) treated with enalapril for 30
days (15 mg/Kg/day) and Control (C) with tap water. We
measured: indirect SBP, androgen, estradiol and FSH plasma
levels, and NOS activity (14C-arginine) in the kidney, aorta and
heart at the end of treatment.
Results: treatment with enalapril did not induce any changes in
SBP, estradiol, androgen and FSH plasma levels.
NOS activity (pmol/min 100g tissue), * p<0.01 vs Control
RenalCortex RenalMedulla Right atria LeftventricleAortaartery
C 370.5±8.1 430.7±16.3 318.3±3.2 218.5±5.3 267.0±4.2
E 396.0±6.7* 498.3±5.8* 341.8±5.8* 243.8±7.2* 306.2±7.0*
Conclusions: The ACE inhibition did not modify SBP or sexual
hormones in normotensive menopause rats, but treatment with
enalapril improved NOS activity significantly in all the studied
tissues. This fact could improve renal and cardiovascular function
during menopause.