Protein acetylation and synaptic composition during Inhibitory Avoidance long-term memory consolidation in mouse hipppocampus

ESQUIVEL, LAURA; KRAWCZYK, MARIA; FREUDENTHAL, RAMIRO; RIVAS, RICARDO SEBASTIÁN; BUSSO, JULIA; BOCCIA, MARIANO; SALLES, ANGELES; BAEZ, VERONICA

Ciudad Autonoma de Buenos Aires

Simposio; Frontera en Biociencia 3; 2018

Instituto de Investigación en Biomedicina de Buenos Aires

Protein acetylation affects synaptic plasticity and memory, but its effects on synapse composition ?in vivo? during long term memory consolidation have not been addressed. Here we show that there is a correlation between the synaptic protein acetylation level and the synaptic protein composition at hippocampus during memory consolidation. We also show that altering the acetylation levels by administration of a Lysine deacetylase inhibitor specific for KDAC6 (mainly cytoplasmic) immediately after training facilitates retention at testing. These results suggest that the post translation modification, lysine acetylation, has a role regulating the synaptic changes that occur during memory consolidation.