IFIBYNE 05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
The Histone Methyltransferase G9a Controls Axon Growth by Targeting the RhoA Signaling Pathway
Autor/es:
WILSON, CARLOS; FISZBEIN, ANA; WILSON, CARLOS; FISZBEIN, ANA; GIONO, LUCIANA E.; KORNBLIHTT, ALBERTO R.; GIONO, LUCIANA E.; KORNBLIHTT, ALBERTO R.; ROZÉS-SALVADOR, VICTORIA; CÁCERES, ALFREDO; ROZÉS-SALVADOR, VICTORIA; CÁCERES, ALFREDO
Revista:
Cell Reports
Editorial:
Elsevier B.V.
Referencias:
Año: 2020 vol. 31
ISSN:
2211-1247
Resumen:
Wilson et al. report that G9a allows the establishment of neuronal polarity, axon growth, and neuronal cortical migration. Through a H3K9me2-dependent mechanism, G9a regulates the expression of Lfc, a RhoGEF that promotes RhoA/ROCK signaling. This report links histone methylation with neuronal polarization and axonal development.
