Cross-talk between bone morphogenetic proteins (BMPs) and WNT signaling pathways in hair follicle stem cells differentiation. Implication in androgenetic alopecia.

LEIRÓS, GUSTAVO JOSÉ; OPPENHEIMER, FLORENCIA MAIA; CERUTI, JULIETA MARÍA; BALAÑÁ, MARÍA EUGENIA

Mar del Plata

Congreso; LXIII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2018

Sociedad Argentina de Investigación Clínica

➢ During androgenetic alopecia (AGA) androgens cause hair follicle miniaturization and baldness throughmechanisms which remain unclear.➢ We previously reported that androgens impair dermal papilla- induced hair follicle stem cell (HFSC)differentiation inhibiting Wnt signalling suggesting that dermal papilla- secreted factors involved innormal HFSC differentiation are deregulated.➢ Dihydrotestosterone (DHT) stimulation downregulated Wnt5a and Wnt10b mRNA while Dkk-1 wasupregulated in DPC microspheres. WNT10b secreted by dermal papilla cells (DPC) overcame the HFSCdifferentiation inhibition involved in androgen-driven balding.➢ The HF bulb microenvironment is rich in bone morphogenetic proteins (BMPs)