ICT - MILSTEIN   05483
INSTITUTO DE CIENCIA Y TECNOLOGIA "DR. CESAR MILSTEIN"
Unidad Ejecutora - UE
artículos
Título:
Uncovering Viral Protein-Protein Interactions and their Role in Arenavirus Life Cycle.
Autor/es:
LOUREIRO, M.E.; DANTUONO, A.; LEVINGSTON MACLEOD, J.M.; LÓPEZ, N.
Revista:
Viruses
Editorial:
MDPI
Referencias:
Lugar: Basel; Año: 2012 vol. 4 p. 1651 - 1667
ISSN:
1999-4915
Resumen:
Abstract: The Arenaviridae family
includes widely distributed pathogens that cause severe hemorrhagic
fever in humans. Replication and packaging of their single-stranded RNA
genome involve RNA recognition by viral proteins and a number of key
protein-protein interactions. Viral RNA synthesis is directed by the
virus-encoded RNA dependent-RNA polymerase (L protein) and requires
viral RNA encapsidation by the Nucleoprotein. In addition to the role
that the interaction between L and the Nucleoprotein may have in the
replication process, polymerase activity appears to be modulated by the
association between L and the small multifunctional Z protein. Z is also
a structural component of the virions that plays an essential role in
viral morphogenesis. Indeed, interaction of the Z protein with the
Nucleoprotein is critical for genome packaging. Furthermore, current
evidence suggests that binding between Z and the viral envelope
glycoprotein complex is required for virion infectivity, and that Z
homo-oligomerization is an essential step for particle assembly and
budding. Efforts to understand the molecular basis of arenavirus life
cycle have revealed important details on these viral protein-protein
interactions that will be reviewed in this article.