Actividad antibacteriana de antraquinonas naturales.

COMINI LR, NÚÑEZ MONTOYA SC, PÁEZ PL, ALBESA I, CABRERA JL.

Córdoba

Simposio; X SIMPOSIO ARGENTINO Y XIII SIMPOSIO LATINOAMERICANO DE FARMACOBOTANICA.; 2010

Dpto. Farmacia, Fac. Cs. Qcas., UNC. IMBIV-CONICET

The photodynamic antimicrobial chemotherapy, involves photosensitizers (PS) and visible or ultraviolet light and has been proposed in the treatment of locally occurring infections (caries, periodontal diseases, oral candidiosis) and infected wounds. Some PS produces bacterial photoinactivation through a photodynamic photosensitization acting mainly through the generation of reactive oxygen species (ROS), particularly singlet molecular oxygen (1O2)1. Heterophyllaea pustulata Hook f. (Rubiaceae) is a phototoxic vegetal species popularly known as “cegadera”. From leaves and stems nine AQs: soranjidiol, soranjidiol-1-methyl ether, rubiadin, rubiadin-1-methyl ether, damnacanthal, damnacanthol, heterophylline, pustuline and 5,5´-bisoranjidiol were isolated and identified. In complementary studies we have demonstrated that these AQs exhibit photosensitizing properties by generation of superoxide anion (O2•_) and/or 1O2. Our aim was to determine whether the isolated AQs from H. pustulata have antibacterial effect on Staphylococcus aureus and whether this effect is due solely to a photodynamic process or to a concurrent combination between both driven processes: under irradiation and darkness.