MODIFICATION AND CHARACTERIZATION OF MAGNETIC MAGHEMITE NANOPARTICLES WITH DENDRITIC MOLECULES

JULIETA I. PAEZ; ARIEL L. CAPPELLETTI; VERÓNICA BRUNETTI; MIRIAM C. STRUMIA

Los Cocos - Córdoba

Congreso; ARCHIPOL 09; 2009

Grupo de Polímeros Argentinos-Chilenos

modification and characterization of magnetic maghemite nanoparticles with dendritic molecules Julieta Paez†, Ariel Cappelletti†, Verónica Brunetti and Miriam Strumia‡ † IMBIV-CONICET, Departamento de Química Orgánica and ‡ INFIQC-CONICET, Departamento de Fisicoquímica. Facultad de Ciencias Químicas. Universidad Nacional de Córdoba. Haya de la Torre y Medina Allende. Ciudad Universitaria (5000). Córdoba. Argentina. E-mail: juli_paez@yahoo.com.ar     Introduction Dendritic molecules have proved to be useful for functionalization of metallic surfaces due to their monodisperse nature that provides precisely controlled size, shape and functionality.[1] In our group, we have been working on functionalization of gold and carbon electrodes with a dendritic molecule (D-NO2).[2,3] The promising results obtained on these surfaces, encouraged us to explore the functionalization of magnetic nanoparticles (MNPs) with such molecule.[4] MNPs possess high surface area and unique magnetic properties with a broad range of potential biomedical applications[5-8] (e.g., diagnostic medicine, hyperthermia, cell labeling and sorting, separation o cells), and other nonbiomedical uses[9] (e.g. high-density memory devices, magnetic sensors, imaging reagents, ferrofluids). In recent years there has been a significant progress in the application of these novel nanomaterials in biosensors.[10] In this opportunity, we present the preparation and characterization of dendritic molecule-coated MNPs. Afterwards, the immobilization of these modified MNPs onto glassy carbon electrodes (GCE) was explored to generate a novel platform promising for the development of biosensors.