IMBIV 05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Acute toxicity evaluation in vivo of the natural anthraquinones.
Autor/es:
COMINI L., FERNANDEZ I., NUÑEZ S., CABRERA J. Y RIVAROLA V.
Lugar:
Ciudad autónoma de Buenos Aires, Argentina
Reunión:
Jornada; X JORNADAS ANUALES DE LA SOCIEDAD ARGENTINA DE BIOLOGÍA.; 2008
Institución organizadora:
Soc. Arg. de Biología (SAB)
Resumen:
Rubiadin (1) and soranjidiol (2), are anthraquinones (AQs) isolated from the phototoxic plant Heterophyllaea pustulata, which exhibits photosensitizers properties, with the ability to produce both singlet oxygen and/or superoxide anion under radiation condition. An important research line studies photosensitizers compounds and their potential uses in photodynamic therapy, oriented mainly in antitumoral therapy.
Regarding these antecedents we evaluated the photodynamic activity of these AQs in vitro against a human breast carcinoma cell line, obtaining satisfactory results. Therefore, the next step would be to evaluate their photodynamic activity in vivo.
