Biosynthesis of metallic nanoparticles and oxidative stress induced in bacteria

PÁEZ PL., QUINTEROS MA., AIASSA MARTÍNEZ IM., FUNES CM., DALMASSO PR., ALBESA I.

Buenos Aires

Congreso; VIII Meeting of the Society for Free Radical Biology and Medicine-South American Group (VIII SFRBM-SAG); 2013

Universidad de Buenos Aires

Since the emergence of antibiotics, it has been possible to eradicate a wide range of infectious diseases that threaten human health. However, microorganisms, such as bacteria, have developed a wide variety of resistance mechanisms for evading their inhibitory effects. As science has advanced toward the development of new therapeutic agents, the number of bacterial strains resistant to the last line of antibiotic defense has increased. With the emergence of multidrug-resistant bacteria, the antibiotic of choice has had to be replaced or its dose increased. Nanoparticles show unique physical and chemical properties and have attracted much attention for their distinct characteristics. That?s because they represent an increasingly important material in the development of nanotechnology and nanoparticles which can be used in numerous applications. Microorganisms play an important role in the eco-friendly synthesis of metal nanoparticles. Resistance of bacteria to antimicrobial agents has increased in recent years. Nanoparticles interaction with biomolecules and microorganisms is expanding the field of research. This study illustrates the synthesis of silver nanoparticles (Ag-Nps) and their antibacterial activity. Moreover, focuses on the processes resulting in oxidative stress and on up-to-date studies of Ag-NPs-induced intracellular changes leading to such stress in microorganisms.