Activity and free radical generation in Staphylococcus aureus induced by N-Benzenesulfonyl 1,2,3,4- tetrahydroquinoline

MARTINEZ SR; MIANA GE; VILLEGAS VENENCIA NV; ALBESA I; MAZZIERI MR; BECERRA MC

Cordoba

Jornada; VI Jornadas de Posgrado. Fac. Ciencias Químicas, UNC.; 2013

Fac. Cs. Qcas. UNC.

Staphylococcus aureus, both in the healthcare setting and the community prompts great urgency in the development of and advocacy for prevention and treatment efforts. The continous appearance of resistant strains requires an urgent search for new compounds (1). A chemical library of 109 N-benzenesulfonyl derivatives of bioactive heterocyclic compounds was design and prepared. Two of them have already demonstrated antibacterial activity and also have been involved in generating reactive oxygen species (ROS) (2), that could be an effect associated to the mechanism of antibacterial action (3). The objective was to investigate the antibacterial activity of N-Benzenesulfonyl- 1,2,3,4- tetrahydroquinoline (BS-THQ) and ROS generation.