Síntesis y caracterización de películas de quitosano modificadas en una de las caras con dendrones

ANA AGUSTINA ALDANA; STRUMIA M.; MARISA MARTINELLI

Taller; 2º Taller de Órganos Artificiales, Biomateriales e Ingeniería de Tejidos, OBI 2011; 2011

Dendronized polymers represent an alternative with a variety of shapes, core molecules, carbohydrate residues and valences. The incorporation of dendritic structures onto polymeric supports is an effective means for amplifying the number and specificity of functional groups along the polymeric surface. The modification of chitosan with dendritic structures is a novel and interesting path to synthesize highly functionalized and unconventional polysaccharide-based products that may be of interest for various applications, for example, as wound dressing, drug delivery systems and catalysts. Wound dressing is one of the most promising medical applications for chitosan. The adhesive nature of chitosan, together with their antifungal and bactericidal character, and their permeability to oxygen, is a very important property associated with the treatment of wounds and burns. In this work, we have developed dendronized chitosan films on one side (dCh). dCh films were obtained by reaction between crosslinked biopolymer and di-t-butyl-4-[2-(t-butoxycarbonyl)ethyl]-4-isocyanato-1,7-heptanedicarboxylate dendron. We had studied these films by different assays like ATR-FTIR, contact angle and swelling behavior. Our results indicate that these films are two different faces: one is more hydrophobic than the other. dCh films were stable to pH 3.4 at prolonged time. They can be use as wound dressings to maintain a moist environment at the wound interface.