Thermosensitive nanogels based in dendritic polyglycerol and n-isopropylacrylamide

JULIO C. CUGGINO; CECILIA I. ALVAREZ I.; MIRIAM C. STRUMIA; PIA WELKER; KAI LICHA ; DIRK STEINHILBER; RADU-CRISTIAN MUTIHAC; MARCELO CALDERÓN

Mar del Plata

Taller; 2° Taller de Órganos Artificiales, Biomateriales e Ingeniería de Tejidos; 2011

In this work we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels in solid and solution phase, as well as the cell toxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced non-cytotoxic profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for the application as smart, enviromental-responsive material.