CIQUIBIC   05472
CENTRO DE INVESTIGACIONES EN QUIMICA BIOLOGICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Synapsin induce proliferation of T-cell lines against myelin basic protein obtained from rats with Experimental autoimmune encephalomyelitis
Autor/es:
DEGANO ALICIA L.; ROTH GERMAN A.
Revista:
AUTOIMMUNITY
Editorial:
Informa UK
Referencias:
Año: 2009 vol. 42 p. 661 - 668
ISSN:
0891-6934
Resumen:
Abstract
We have previously described that antibodies and T cells against myelin basic protein (MBP) rose under conditions to induce
acute experimental autoimmune encephalomyelitis (EAE) bind other proteins present in the synaptosomal fraction, some of
them identified as synapsin I. The aim of this study was to evaluate whether anti-MBP T-cell lines can be also activated by
synapsin. The analysis of rat anti-MBP T-cell lines cultured with each antigen showed that these cells responded also to
purified rat synapsin and to the amino terminal portion of this protein. This recognition originated a proliferative response
with a concomitant pattern of cytokine secretion similar to that induced by MBP itself implicating that this recognition would
be mediated by the T-cell receptor. On the other hand, anti-synapsin T-cell lines were not capable of responding to MBP
stimulation. Therefore, the immunological cross-reactivity between both proteins occurs only in one direction and these crossreactive
cells would be elicited only in animals sensitized with MBP. A possible implication of immunological agents against
MBP cross-reactive with extra-myelin proteins in the process of EAE is considered.