CIQUIBIC 05472
CENTRO DE INVESTIGACIONES EN QUIMICA BIOLOGICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Adsorption kinetics of c-Fos and c-Jun to air-water interfaces
Autor/es:
DEL BOCA M.,; THATYANE, M. N.; GRACIELA ADRIANA BORIOLI; ELISABETE, D. Z. M.; BRUNO MAGGIO,
Revista:
Biophysical Chemistry
Referencias:
Año: 2007 vol. 130 p. 132 - 138
ISSN:
0301-4622
Resumen:
The kinetics of adsorption to airwater interfaces of the biomembrane active transcription factors c-Fos, c-Jun and their mixtures is investigated. The adsorption process shows three distinct stages: a lag time, a fast pseudo zero-order stage, and a halting stage. The initial stage determines the course of the process, which is concentration dependent until the end of the fast stage. We show that c-Fos has faster adsorption kinetics than c-Jun over all three stages and that the interaction between both proteins is apparent in the adsorption profiles of the mixtures. Protein molecular reorganization at the interface determines the transition to the final adsorption stage of the pure proteins as well as that of the mixtures.
