INIMEC - CONICET 05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
artículos
Título:
Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation
Autor/es:
VERÓNICA TRUJILLO; MARÍA LUJAN MASSERONI; GLORIA LEVIN; MARTA MAGDALENA SUÁREZ
Revista:
THE INTERNATIONAL JOURNAL OF NEUROSCIENCE.
Referencias:
Año: 2008
ISSN:
0020-7454
Resumen:
The aim of this work was to determine the effect of chronic treatment with 5 mg/Kg of tianeptine in male adult Wistar rats separated from the mother as neonates, and submitted to variable chronic stress, on plasma catecholamines and anxiety. The Plus Maze test was performed in order to calculate the anxiety index, and catecholamine levels were determined by HPLC.
Both stress and maternal-separation elevated catecholamine levels without affecting the anxiety. In the maternally separated-stress group, tianeptine decreased epinephrine. In the maternally separated-unstressed group tianeptine reduced anxiety and it also showed a tendency to lower anxiety index in all groups.
