Could Maitake D-Fraction inhibits the malignant phenotype in breast cancer?.

E. ALONSO, D. OBIOL AND G. BALOGH.

Rosario

Congreso; II Reunión Internacional de Ciencias Farmacéuticas. RICIFA.; 2012

Facultad de Bioquímica y Farmacia - Universidad Nacional de Rosario

Maitake D-Fraction is a standardized form of isolated b-glucan polysaccharide and proteins. This fraction is obtained both the mycelia and fruit body of Basidiomycete Grifola frondosa (Maitake) (1). Maitake D-Fraction has demonstrated the most potent immune enhancement and antitumor, resulting in the highest reduction rate in cancer proliferation (2,3). Also, it has been shown to have an antitumor effect on tumor-bearing mice (2). Is already known that D-Fraction acts through activation of various immune effectors that targeting tumor cells, including macrophages (4,5,6), natural killer (4,6,7), T lymphocyte subsets Th-1 (8,9,10), cytotoxic T-cells (5) and denditrics cells (10). Moreover, D-Fraction acts directly on the tumor cell, inducing apoptosis (11,12,13), and modulating specifics molecular targets of the neoplasic cell (13). However, the exact molecular mechanism of Maitake antitumor effect is still unclear. At the present work we are identifying which genes are responsible for the suppression of the tumoral phenotype induced by Maitake D-Fraction in breast cancer cells.